Anatomic modeling plays an important role in understanding human anatomy and disease and ultimately how your device performs in worst-case patient populations. Each person is unique, and so are the diseases and disease states that result in morphologic changes within the body. Developing a physiologic model for a diverse patient population to be used for design verification testing is a significant challenge. We can create physiological models that mimic the clinical environment by leveraging cadaveric models, experience of physicians, as well as other sources. These inputs combined with our experience have helped us create clinically relevant models and their associated justifications to evaluate device safety for many customers.